Skip to main content
. 2019 Jul;209:41–53. doi: 10.1016/j.biomaterials.2019.04.014

Fig. 2.

Fig. 2

Enhanced cardiac function by MSC-dressing therapy in a rat heart failure model. Four weeks after left coronary artery ligation in rats, MSC-dressings (containing 1, 2 or 4 × 106 rat amnion-derived MSCs; DR-1m, DR-2m, DR-4m groups, respectively), fibrin sealant film only (DR-0 group), or no treatment (Sham group) were placed onto the heart surface. Additional animals received IM injection of 4 × 106 MSCs (IM-4m group). At 28 days post-treatment, cardiac function and structure measured by using echocardiography (a) and catheterization (b). LVEF, left ventricular ejection fraction; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; LVEDP, left ventricular end-diastolic pressure, n = 9–10 in each group; *p < 0.05 vs. Sham and DR-0 groups, †p < 0.05 vs. DR-1m group, ‡p < 0.05 vs. IM-4m group. One-way ANOVA.