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. 2019 Jul;209:41–53. doi: 10.1016/j.biomaterials.2019.04.014

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 6 — Long-term effect of MSC-dressing therapy in a rat heart failure model. Four weeks after left coronary artery ligation, rats received MSC-dressing therapy (containing 4 × 10⁶ rat amnion-derived MSCs; DR-4m group), IM injection of 4 × 10⁶ rat amnion-derived MSCs (IM-4m group), or no treatment (Sham group). At 90 days after these treatments, cardiac function and structure were measured by using echocardiography (a) and cardiac catheterization (b). LVEF, left ventricular ejection fraction; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; LVEDP, left ventricular end-diastolic pressure, n = 9–10 in each group; *p < 0.05 vs. Sham group, ^†p < 0.05 vs. IM-4m group. One-way ANOVA.