Table 2.
The number of cases with high Genomic Instability Index (GII) and predicted homologous recombination deficiency (HRD) based on three scores (tAI, LOH, and LST).
| Score | Criteria | pCR | pIR | P-value |
|---|---|---|---|---|
| GII | High > 0.286 | 7 | 11 | 0.712 |
| Low < 0.286 | 4 | 11 | ||
| nTAI | >14 | 4 | 14 | 0.163 |
| < 14 | 7 | 8 | ||
| HRD-LOH | >10 | 3 | 2 | 0.304 |
| < 10 | 8 | 20 | ||
| LST | >15 if 2N or >20 if 4N | 2 | 0 | 0.118 |
| < 15 if 2N or < 20 if 4N | 9 | 22 |
GII, Genomic Instability Index; nTAI, number of telomere allelic imbalance; HRD-LOH, Loss of heterozygosity score; LST, Large Scale Transition score; calculated as described in Material and Methods session.