Figure 2.

The characteristics of tumor cells and respective targeted therapies. Deregulated metabolism can be targeted with pro-aerobiotic glycolysis inhibitors (52); deregulated cell cycle and increased uncontrolled cellular proliferation can be targeted with pro-apoptotic BH3 mimetics (76, 127); acquired genome instability can be targeted with PARP inhibitors (164); the evasion mechanisms of tumor cell from the anti-tumoral immune response can be controlled by immune activating mAbs (165); enhanced migration capacity of the tumor cell can be targeted with inhibitors HGF/c-Met (166); the angiogenic capacity can be shunted using inhibitors for VEGF signaling; pro-inflammatory properties of the tumor cell can be hindered by selective anti-inflammatory drugs (167).