Table 1.
Cell membrane properties of spiny projection neurons (SPNs) in wildtype (WT), Q175 and R6/2 mice.
| Capacitance (pF) | Input resistance (MΩ) | Time constant (ms) | |
|---|---|---|---|
| 2 months | |||
| WT (n = 47) | 147.6 ± 6.3 | 49.8 ± 2.9 | 2.1 ± 0.08 |
| Q175 (n = 49) | 143.6 ± 5.1 | 55.0 ± 3.0 | 2.1 ± 0.08 |
| 8 months | |||
| WT (n = 38) | 132.6 ± 4.4 | 64.4 ± 3.6 | 2.2 ± 0.08 |
| Q175 (n = 33) | 125.1 ± 5.7 | 84.9 ± 6.7** | 2.1 ± 0.08 |
| 12 months | |||
| WT (n = 40) | 97.4 ± 6.1 | 78.1 ± 6.1 | 1.8 ± 0.10 |
| Q175 (n = 47) | 88.7 ± 3.8 | 107.5 ± 6.8** | 1.8 ± 0.08 |
| 60 days | |||
| WT (n = 38) | 118.8 ± 6.7 | 66.0 ± 8.3 | 1.8 ± 0.1 |
| R6/2 (n = 53) | 80.0 ± 1.9**** | 161.9 ± 9.1**** | 1.5 ± 0.05** |
Group means ± SEMs are reported. Comparisons for each membrane property were made between WT and Q175 or R6/2 cells at each age group. Significant differences were determined using Student’s t-tests where **p < 0.01 and ****p < 0.0001.