Table 7.
Multifactorial ordinal logistic regression for associations with unfavorable 90 day mRS.
| Pneumonia (n = 791 patients) | Any infection (n = 2254 patients) | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p | OR | 95% CI | p | |
| Antibiotic class | ||||||
| Lincosamides and tetracyclines | 0.95 | 0.62 to 1.45 | 0.82 | 1.37 | 0.98 to 1.91 | 0.07 |
| Cephalosporins, carbapenems, and monobactams | 1.31 | 0.96 to 1.78 | 0.09 | 1.62 | 1.33 to 1.97 | <0.001 |
| Aminoglycosides | 1.04 | 0.62 to 1.76 | 0.87 | 1.73 | 1.22 to 2.46 | 0.002 |
| Fluoroquinolones | 1.05 | 0.77 to 1.44 | 0.74 | 1.22 | 1.01 to 1.47 | 0.040 |
| Penicillins | 0.95 | 0.62 to 1.44 | 0.81 | 1.16 | 0.89 to 1.52 | 0.28 |
| Penicillin plus β-lactamase inhibitor | 0.94 | 0.69 to 1.28 | 0.68 | 1.26 | 1.03 to 1.54 | 0.025 |
| Other* | 1.30 | 0.72 to 2.35 | 0.38 | 1.48 | 1.21 to 1.82 | <0.001 |
| Macrolides | 0.46 | 0.29 to 0.73 | 0.001 | 0.59 | 0.42 to 0.83 | 0.004 |
| Sex | ||||||
| Female | Ref | Ref | ||||
| Male | 1.02 | 0.79 to 1.33 | 0.86 | 1.02 | 0.87 to 1.19 | 0.84 |
| Increasing age (y) | 1.05 | 1.04 to 1.06 | <0.001 | 1.05 | 1.04 to 1.05 | <0.001 |
| Baseline NIHSS | 1.11 | 1.08 to 1.15 | <0.001 | 1.15 | 1.13 to 1.17 | <0.001 |
| Infection subtype | ||||||
| Pneumonia | 1.47 | 1.09 to 1.97 | 0.011 | |||
| Tracheobronchitis | 0.92 | 0.63 to 1.36 | 0.69 | |||
| Urogenital | 0.64 | 0.48 to 0.85 | 0.002 | |||
| Other | 0.77 | 0.57 to 1.02 | 0.097 | |||
| Uncertain | 1.17 | 0.86 to 1.58 | 0.31 | |||
| Treated with IV alteplase | ||||||
| No | Ref | Ref | ||||
| Yes | 0.95 | 0.70 to 1.29 | 0.73 | 0.80 | 0.66 to 0.96 | 0.016 |
| Prior statin | ||||||
| No | Ref | Ref | ||||
| Yes | 1.14 | 0.30 to 2.16 | 0.69 | 1.14 | 0.83 to 1.57 | 0.42 |
| Unrecorded | 1.71 | 0.96 to 3.02 | 0.07 | 1.62 | 1.18 to 2.23 | 0.003 |
| Smoking status | ||||||
| Non-smoker | Ref | Ref | ||||
| Smoker | 1.29 | 0.67 to 2.16 | 0.69 | 1.21 | 0.83 to 1.57 | 0.42 |
| Unrecorded | 1.15 | 0.49 to 2.68 | 0.75 | 1.04 | 0.65 to 1.67 | 0.88 |
| Region | ||||||
| Australasia/ Africa | Ref | Ref | ||||
| Asia | 0.85 | 0.39 to 1.85 | 0.68 | 1.14 | 0.68 to 1.92 | 0.62 |
| Europe | 0.85 | 0.41 to 1.77 | 0.66 | 1.10 | 0.67 to 1.79 | 0.72 |
| America | 0.92 | 0.44 to 1.96 | 0.84 | 1.03 | 0.62 to 1.69 | 0.91 |
| Increasing year of study | 0.97 | 0.90 to 1.04 | 0.41 | 1.00 | 0.96 to 1.04 | 0.88 |
*
Other includes sulphonamides/folic acid inhibitors, metronidazole, glycopeptides and nitrofurans.
mRS, modified Rankin Scale; OR, Odds ratio; CI, Confidence Interval; NIHSS, National Institutes of Health Stroke Scale; IV, intravenous.