Table 9.

Multifactorial ordinal logistic regression for associations with worse 90 day NIHSS.

	Pneumonia (n = 781 patients)			Any infection (n = 2215 patients)
	OR	95% CI	P	OR	95% CI	p
Antibiotic class
Lincosamides and tetracyclines	0.96	0.63 to 1.46	0.86	1.33	0.96 to 1.85	0.09
Cephalosporins, carbapenems, and monobactams	1.26	0.93 to 1.70	0.14	1.56	1.28 to 1.90	<0.001
Aminoglycosides	1.09	0.65 to 1.85	0.74	1.81	1.27 to 2.58	0.001
Fluoroquinolones	1.01	0.74 to 1.38	0.95	1.18	0.98 to 1.43	0.09
Penicillins	1.06	0.68 to 1.66	0.79	1.12	0.86 to 1.46	0.40
Penicillin plus β-lactamase inhibitor	0.95	0.70 to 1.29	0.73	1.26	1.04 to 1.53	0.02
Other*	1.34	0.74 to 2.44	0.34	1.33	1.08 to 1.63	0.006
Macrolides	0.59	0.37 to 0.94	0.03	0.67	0.56 to 0.80	0.007
Sex
Female	Ref			Ref
Male	1.12	0.86 to 1.45	0.41	1.08	0.92 to 1.26	0.34
Increasing age (y)	1.04	1.02 to 1.05	<0.001	1.03	1.02 to 1.04	<0.001
Baseline NIHSS	1.14	1.11 to 1.18	<0.001	1.18	1.16 to 1.20	<0.001
Infection subtype
Pneumonia				1.57	1.17 to 2.11	0.003
Tracheobronchitis				0.95	0.65 to 1.38	0.78
Urogenital				0.68	0.51 to 0.91	0.008
Other				0.84	0.61 to 1.14	0.27
Uncertain				1.15	0.85 to 1.56	0.37
Treated with IV alteplase
No	Ref
Yes	0.93	0.69 to 1.27	0.66	0.78	0.65 to 0.93	0.007
Prior statin
No	Ref
Yes	1.06	0.56 to 2.00	0.87	1.00	0.73 to 1.38	0.99
Unrecorded	1.51	0.86 to 2.64	0.15	1.24	0.91 to 1.69	0.18
Smoking status
Non-smoker	Ref
Smoker	1.17	0.63 to 2.20	0.62	1.08	0.74 to 1.56	0.70
Unrecorded	1.04	0.45 to 2.39	0.93	0.97	0.60 to 1.54	0.88
Region
Australasia/Africa	Ref
Asia	1.19	0.55 to 2.59	0.66	1.59	0.95 to 2.64	0.08
Europe	0.97	0.47 to 2.01	0.94	1.18	0.73 to 1.90	0.51
America	1.05	0.50 to 2.22	0.90	1.16	0.71 to 1.90	0.54
Increasing year of study	0.96	0.90 to 1.04	0.32	0.99	0.95 to 1.03	0.57

^*Other includes sulphonamides/folic acid inhibitors, metronidazole, glycopeptides and nitrofurans.

OR, Odds ratio; CI, Confidence Interval; NIHSS, National Institutes of Health Stroke Scale; IV, intravenous.