Figure 3: Efavirenz-associated QT Prolongation and Torsade de Pointes Arrhythmia.

Representative ECG recordings from a 63-year old woman with HIV who developed efavirenz-related QT prolongation and torsade de pointes arrhythmia. A: Sinus rhythm at 95 bpm and QT alternans. B: Sinus bradycardia, marked QT interval prolongation and onset of a TdP arrhythmia that required cardioversion for termination. C: The arrhythmia could be suppressed by overdrive ventricular pacing at a rate of 100 bpm. QT prolongation and non-sustained TdP episodes developed when the pacing rate was lowered to <100 bpm. QT returned to normal several days after discontinuation of the long-acting efavirenz. Source: Castillo R, et al. 2002.9 Reproduced with permission from © SAGE Publications.