Fig. 2.

Neurocognitive profile of pediatric (i.e., < 18 years old) and adult (i.e., ≥18 years old) female carriers of NHE6 mutations. a Age distribution of all enrolled female carriers (i.e., age at enrollment). b Age distribution of female carriers with neurocognitive assessments (i.e., age at testing). c–i Comparison of pediatric versus adult female carriers across neurocognitive domains. Pearson correlation analyses were conducted to examine the association between age (i.e., pediatric or adult) and neurocognition. There were no statistically significant age effects found in any domain. Ages of pediatric female carriers (n = 4) ranged from approximately 4–17 years (average age 10.3 ± 4.6 years); ages of adult female carriers (n = 9) ranged from approximately 25–55 years (average age 38.9 ± 9.3 years). All neurocognitive domains were assessed in the 4 pediatric participants, except for language (n = 3). Neurocognitive data are reported as mean ± SEM.