Table 3.

Correlation between NHE6 expression in brain and Alzheimer's disease variables in aging/dementia cohorts

NHE6 variant	Aβ load				Tau tangle density
	intercept	beta	unadj. p value	adj. p value	intercept	beta	unadj. p value	adj. p value
NHE6 (ENSG00000198689.5)	−0.152	−0.018	0.038	0.204	−0.696	−0.028	0.008	0.051
NHE6: isoform 1 (ENST00000370698.3)	−0.424	−0.016	0.208	0.664	−1.631	0.032	0.035	0.213
NHE6: isoform 2 (ENST00000370695.4)	−0.586	0.004	0.833	0.961	−1.244	−0.037	0.074	0.332
NHE6: isoform 3 (ENST00000370701.l)	−0.482	−0.007	0.259	0.706	−1.028	−0.024	0.002	0.031

	Neurofibrillary tangles				Alzheimer's disease pathology
	intercept	beta	unadj. p value	adj. p value	intercept	beta	unadj. p value	adj. p value
NHE6 (ENSG00000198689.5)	−0.485	−0.005	0.155	0.496	−6.189	−0.034	0.053	0.303
NHE6: isoform 1 (ENST00000370698.3)	−0.625	0.004	0.408	0.828	−6.886	−0.005	0.843	0.995
NHE6: isoform 2 (ENST00000370695.4)	−0.575	−0.005	0.391	0.820	−6.884	−0.020	0.566	0.923
NHE6: isoform 3 (ENST00000370701.1)	−0.554	−0.003	0.215	0.710	−6.671	−0.024	0.052	0.510

	Cognitive decline				Neuropathological severity
	intercept	beta	unadj. p value	adj. p value	intercept	beta	unadj. p value	adj. p value
NHE6 (ENSG00000198689.5)	−0.205	0.002	0.029	0.150	−0.100	−0.008	0.055	0.245
NHE6: isoform 1 (ENST00000370698.3)	−0.143	−0.002	0.177	0.616	−0.317	0.003	0.614	0.872
NHE6: isoform 2 (ENST00000370695.4)	−0.168	0.004	0.040	0.320	−0.279	−0.003	0.687	0.902
NHE6: isoform 3 (ENST00000370701.1)	−0.175	0.001	0.058	0.385	−0.218	−0.006	0.062	0.408