Table 3.
SNPs From Table 2 With the Analysis Stratified by COPD Case–Control Status Among COPDGene NHW
| SNP | CHR | Nearest gene | Coded allele | COPDGene NHW COPD cases (n = 2819) | COPDGene NHW COPD controls (n = 2534) | Interaction of COPD and SNP on CPD (n = 5353) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele freq | β | p | Allele freq | β | p | Allele freq | β | p | |||||
| Chromosome 15q25 | rs8192482 | 15 | CHRNA3 | T/T/T/T | 0.39 | 0.11 | 5.58E-4 | 0.34 | 0.12 | 3.86E-5 | 0.37 | -0.02 | .61 |
| rs11633958 | 15 | CHRNA5 | T/T/T/T | 0.39 | 0.11 | 5.06E-4 | 0.34 | 0.12 | 5.34E-5 | 0.37 | -0.02 | .66 | |
| rs72738786 | 15 | AGPHD1 | T/T/T/T | 0.39 | 0.11 | 3.33E-4 | 0.34 | 0.12 | 5.81E-5 | 0.37 | -0.01 | .74 | |
| rs2869548 | 15 | CHRNB4 | A/A/A/A | 0.40 | 0.10 | 7.94E-4 | 0.36 | 0.11 | 2.81E-4 | 0.38 | -0.01 | .81 | |
| rs11858836 | 15 | IREB2 | A/A/A/A | 0.38 | 0.08 | 7.17E-4 | 0.33 | 0.11 | 2.36E-4 | 0.36 | -0.03 | .47 | |
| Replicated regions from the UK BiLEVE study | rs61784651 | 1 | LPPR5 | T/T/T/T | 0.15 | -0.01 | 0.90 | 0.16 | -0.05 | 0.24 | 0.15 | 0.04 | .48 |
| rs10193706 | 2 | TEX41/ PABPC1P2 | A/A/C/C | 0.46 | 0.01 | 0.83 | 0.47 | 0.04 | 0.12 | 0.47 | -0.04 | .37 | |
| rs10807199 | 6 | DNAH8 | T/T/T/T | 0.48 | 0.02 | 0.43 | 0.45 | -0.04 | 0.14 | 0.46 | 0.07 | .11 | |
| rs215605 | 7 | PDE1C | G/G/T/T | 0.39 | 0.02 | 0.57 | 0.37 | 0.02 | 0.56 | 0.38 | 0.001 | .98 | |
| rs13280604 | 8 | CHRNB3 | G/G/A/A | 0.21 | 0.05 | 0.15 | 0.22 | 0.02 | 0.53 | 0.22 | 0.03 | .51 | |
| rs3025343 | 9 | DBH | A/A/A/A | 0.12 | -0.02 | 0.64 | 0.12 | 0.01 | 0.82 | 0.12 | -0.03 | .65 | |
| rs1329650 | 10 | LOC100188947 | T/T/T/T | 0.28 | -0.01 | 0.79 | 0.27 | -0.03 | 0.39 | 0.28 | 0.02 | .72 | |
| rs6265 | 11 | BDNF | T/T/T/T | 0.18 | -0.02 | 0.64 | 0.19 | -0.01 | 0.76 | 0.19 | 0.001 | .93 | |
| rs4466874 | 11 | NCAM1 | C/C/C/C | 0.41 | -0.07 | 0.02 | 0.40 | -0.07 | 0.02 | 0.41 | 0.001 | .94 | |
| rs7937 | 19 | RAB4B | C/C/T/T | 0.40 | -0.13 | 2.49E-5 | 0.45 | -0.05 | 0.05 | 0.42 | -0.08 | .07 | |
| rs3733829 | 19 | EGLN2 | G/G/G/G | 0.38 | 0.08 | 0.02 | 0.36 | 0.06 | 0.04 | 0.37 | 0.02 | .72 | |
| rs12461383 | 19 | CYP2A7 | C/C/G/G | 0.46 | -0.1 | 9.63E-03 | 0.48 | -0.06 | 0.09 | 0.47 | -0.04 | .46 | |
| rs7260329 | 19 | CYP2B6 | A/A/A/A | 0.30 | -0.03 | 0.44 | 0.32 | -0.1 | 1.19E-3 | 0.31 | 0.07 | .12 | |
| rs4911243 | 20 | NOL4L | A/A/G/G | 0.34 | 0.04 | 0.24 | 0.33 | 0.05 | 0.12 | 0.34 | -0.01 | .90 | |
CHR = chromosome, CPD = cigarettes per day, COPD = chronic obstructive pulmonary disorder, COPDGene = Genetic Epidemiology of COPD, NHW = non-Hispanic whites, SNPs = single nucleotide polymorphisms. Correcting for the 12 regions listed, all p values less than 4.17E-3 (0.05/12) are in bold.