Table 4.
SNPs From Table 2 With the Analysis Stratified by COPD Case–Control Status Among COPDGene AA
| SNP | CHR | Nearest gene | Coded allele | COPDGene AA COPD cases (n = 821) | COPDGene AA COPD controls (n = 1749) | Interaction of COPD and SNP on CPD (n = 2570) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele freq | β | Allele freq | β | Allele freq | β | Allele Freq | β | p | |||||
| Chromosome 15q25 | rs8192482 | 15 | CHRNA3 | T/T/T/T | 0.06 | 0.08 | 0.06 | 0.08 | 0.06 | 0.08 | 0.06 | 0.06 | .65 |
| rs11633958 | 15 | CHRNA5 | T/T/T/T | 0.07 | 0.13 | 0.07 | 0.13 | 0.07 | 0.13 | 0.06 | 0.14 | .26 | |
| rs72738786 | 15 | AGPHD1 | T/T/T/T | 0.14 | 0.07 | 0.14 | 0.07 | 0.14 | 0.07 | 0.14 | 0.05 | .56 | |
| rs2869548 | 15 | CHRNB4 | A/A/A/A | 0.07 | 0.07 | 0.07 | 0.07 | 0.07 | 0.07 | 0.06 | 0.02 | .86 | |
| rs11858836 | 15 | IREB2 | A/A/A/A | 0.07 | 0.09 | 0.07 | 0.09 | 0.07 | 0.09 | 0.07 | 0.13 | .29 | |
| Replicated regions from the UK BiLEVE study | rs61784651 | 1 | LPPR5 | T/T/T/T | 0.05 | -0.16 | 0.05 | -0.16 | 0.05 | -0.16 | 0.06 | -0.10 | .46 |
| rs10193706 | 2 | TEX41/PABPC1P2 | A/A/C/C | 0.19 | -0.02 | 0.19 | -0.02 | 0.19 | -0.02 | 0.19 | -0.01 | .93 | |
| rs10807199 | 6 | DNAH8 | T/T/T/T | 0.15 | -0.01 | 0.15 | -0.01 | 0.15 | -0.01 | 0.15 | -0.03 | .71 | |
| rs215605 | 7 | PDE1C | G/G/T/T | 0.28 | 0.03 | 0.28 | 0.03 | 0.28 | 0.03 | 0.28 | -0.02 | .79 | |
| rs13280604 | 8 | CHRNB3 | G/G/A/A | 0.27 | -0.08 | 0.27 | -0.08 | 0.27 | -0.08 | 0.28 | 0.05 | .47 | |
| rs3025343 | 9 | DBH | A/A/A/A | 0.03 | 0.06 | 0.03 | 0.06 | 0.03 | 0.06 | 0.02 | -0.05 | .81 | |
| rs1329650 | 10 | LOC100188947 | T/T/T/T | 0.11 | 0.01 | 0.11 | 0.01 | 0.11 | 0.01 | 0.10 | -0.02 | .82 | |
| rs6265 | 11 | BDNF | T/T/T/T | 0.04 | -0.08 | 0.04 | -0.08 | 0.04 | -0.08 | 0.04 | -0.01 | .94 | |
| rs4466874 | 11 | NCAM1 | C/C/C/C | 0.39 | 0.11 | 0.39 | 0.11 | 0.39 | 0.11 | 0.41 | 0.08 | .22 | |
| rs7937 | 19 | RAB4B | C/C/T/T | 0.31 | 0.01 | 0.31 | 0.01 | 0.31 | 0.01 | 0.31 | 0.001 | 1.00 | |
| rs3733829 | 19 | EGLN2 | G/G/G/G | 0.09 | 0.03 | 0.09 | 0.03 | 0.09 | 0.03 | 0.08 | -0.01 | .94 | |
| rs12461383 | 19 | CYP2A7 | C/C/G/G | 0.23 | 0.07 | 0.23 | 0.07 | 0.23 | 0.07 | 0.23 | 0.07 | .34 | |
| rs7260329 | 19 | CYP2B6 | A/A/A/A | 0.16 | -0.07 | 0.16 | -0.07 | 0.16 | -0.07 | 0.15 | -0.03 | .70 | |
| rs4911243 | 20 | NOL4L | A/A/G/G | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.17 | 0.13 | .12 | |
AA = African American, CHR = chromosome, CPD = cigarettes per day, COPD = chronic obstructive pulmonary disorder, COPDGene = Genetic Epidemiology of COPD, SNPs = single nucleotide polymorphisms. Correcting for the 12 regions listed, all p values less than 4.17E-3 (0.05/12) are in bold.