Table 5.

p Values for the Associations of Rare Variants in Each Gene With CPD Using the Genes From Table 2

	CHR	Nearest gene	COPDGene NHW			COPDGene AA
			All (n = 6658)	Cases (n = 2819)	Controls (n = 2534)	All (n = 3260)	Cases (n = 821)	Controls (n = 1749)
Chromosome 15q25	15	CHRNA3	0.17	0.24	0.41	0.52	0.52	0.49
	15	CHRNA5	0.06	0.15	1.00	0.30	0.33	0.45
	15	AGPHD1	0.27	0.01	0.28	0.02	0.43	0.05
	15	CHRNB4	0.87	0.82	0.84	0.87	0.19	0.50
	15	IREB2	0.27	0.77	0.82	0.02	NA	0.15
Replicated regions from the UK BiLEVE study	1	LPPR5	0.83	0.76	0.81	0.19	0.88	0.11
	2	TEX41/PABPC1P2	0.56	0.85	0.22	0.64	1.00	0.33
	6	DNAH8	0.87	0.35	0.87	0.38	0.42	0.51
	7	PDE1C	1.00	0.05	0.14	0.60	0.32	0.74
	8	CHRNB3	0.64	1.00	0.65	0.86	NA	1.00
	9	DBH	0.52	0.64	0.50	0.70	1.00	0.45
	10	LOC100188947	0.87	0.79	0.71	0.11	0.51	0.69
	11	BDNF	1.00	0.76	0.46	0.26	0.48	0.56
	11	NCAM1	0.76	0.30	0.82	0.03	0.27	0.28
	19	RAB4B-EGLN2	0.44	0.69	0.57	0.04	0.15	0.27
	19	CYP2A7	5.2E-4	0.05	0.08	0.47	0.51	0.97
	19	CYP2B6	0.56	0.45	0.03	0.48	0.51	0.21
	20	NOL4L	0.32	0.55	0.89	0.84	NA	NA

AA = African American, CHR = chromosome, CPD = cigarettes per day, COPD = chronic obstructive pulmonary disorder, COPDGene = Genetic Epidemiology of COPD, NA = not applicable, NHW = non-Hispanic white. Correcting for the 12 regions listed, all p values less than 4.17E-3 (0.05/12) are in bold. NAs are given if there were not enough rare variants in the region for the test statistic.