Table 2.
Partial Agonist Imax Values Relative to ACh Maximum
| Receptor | Arecolinea | Isoarecolone | MPA |
|---|---|---|---|
| α4(3)β2(2) | 0.036 ± 0.003 | 0.23 ± 0.03 | 0.28 ± 0.01 |
| α4(2)β2(3) | 0.054 ± 0.004 | 0.32 ± 0.01 | 0.31 ± 0.01 |
| α4(2)β2(2)α5 | 0.16 ± 0.01 | 0.44 ± 0.01 | 0.23 ± 0.01 |
| α6β2β3α4β2 | 0.056 ± 0.003 | 0.45 ± 0.05 | 0.23 ± 0.01 |
| EC50 values (μM) | |||
| α4(3)β2(2) | 75 ± 7 | 440 ± 170 | 253 ± 24 |
| α4(2)β2(3) | 14 ± 3 | 31 ± 5 | 327 ± 7 |
| α4(2)β2(2)α5 | 94 ± 12 | 45 ± 4 | 280 ± 20 |
| α6β2β3α4β2 | 21 ± 4 | 27 ± 1 | 204 ± 18 |
Ach, acetylcholine.
aData on subtypes other than α4(2)β2(2)α5 are taken from Papke et al.,21.