Skip to main content
. 2019 May 21;2019(5):CD009760. doi: 10.1002/14651858.CD009760.pub4

Dos Santos 2017.

Methods Randomised controlled cross‐over trial
Participants Country: Brazil
13 participants (7 men, 6 women); mean age (SD): 56 (18) years; time since stroke not described; educational level 11 out of 13 (85%) elementary school; mean naming accuracy at baseline not described
Inclusion criteria: left hemispheric stroke at least 6 months prior and Broca or anomic aphasia
Exclusion criteria: dysarthria, apraxia of speech, previous speech and language therapy, any clinically significant or unstable medical or psychiatric disorder, history of substance abuse, neuropsychiatric comorbidities
Interventions Each participant underwent all of the following conditions before and after the Boston Naming Test with an intersession interval of unknown length between each condition:
‐ dual tDCS (A‐tDCS over Broca's area and concurrent C‐tDCS over homologous Broca's area) with 2 mA for 20 minutes
‐ TMS over homologous Broca's area with 1 Hz for 20 minutes, using 90% of the motor threshold
‐ sham tDCS with 2 mA for 20 seconds
‐ sham TMS with 1 Hz for 20 seconds
Outcomes Outcomes were recorded at baseline, and at the end of intervention phase:
‐ performance in picture naming
‐ response time
‐ picture‐naming strategy
‐ response time strategy
‐ total response time
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Quote: "The randomization was made by statistic orientation in three weeks ..."
Allocation concealment (selection bias) Unclear risk Not described by the study authors
Blinding of participants and personnel (performance bias) 
 Objective outcomes Unclear risk Objective outcome measures: participants apparently were blinded, blinding of personnel not described by the study authors
Blinding of outcome assessment (detection bias) 
 Objective outcomes Unclear risk Not described by the study authors
Incomplete outcome data (attrition bias) 
 Objective outcomes Unclear risk Objective outcomes: all participants completed the study. No treatment withdrawals, no trial group changes and no major adverse events stated
Selective reporting (reporting bias) Unclear risk All outcomes listed in the 'Methods' section reported, no published protocol could be identified
Other bias Low risk No other bias identified