NCT01486654.

Trial name or title	Transcranial direct current stimulation and aphasia language therapy
Methods	Randomised controlled single‐blind trial
Participants	Estimated enrolment: 12 right‐handed people with single unilateral left‐hemispheric infarction confirmed by CT or MRI, at least 6 months post stroke, age > 21 years, native English speaker Inclusion criteria: non‐fluent aphasia, minimum education: eighth grade, sufficient visual and auditory acuity Exclusion criteria: other neurologic conditions such as Parkinson's disease, Alzheimer's dementia, TBI, significant psychiatric history, active substance abuse, seizures, lesioned premotor cortex
Interventions	3 arms: either ‐ A‐tDCS ‐ C‐tDCS (1 mA, 5 days a week, for 6 weeks) or ‐ S‐tDCS during the first 13 minutes of 90 minutes of speech language treatment
Outcomes	Primary outcome measures: ‐ change from baseline in WAB‐AQ at 6 weeks after the end of intervention period Secondary outcome measures: ‐ change from baseline in functional communication skills at 6 weeks after the end of intervention period (assessed by language sample analyses) ‐ change from baseline in participation in everyday activities at 6 weeks after the end of intervention period (CETI, BOSS, CCRSA) ‐ change from baseline in reading and writing scores of the WAB at 6 weeks after the end of intervention period ‐ change in WAB‐AQ from 6 weeks after the end of intervention period at 12 weeks after the end of intervention period ‐ change in WAB‐reading and writing scores from 6 weeks after the end of intervention period at 12 weeks after the end of intervention period ‐ change from baseline in functional communication from 6 weeks after the end of intervention period in relation to 12 weeks after the end of intervention period (assessed by language sample analyses) ‐ change from baseline in participation in everyday activities from 6 weeks after the end of intervention period in relation to 12 weeks after the end of intervention period (CETI, BOSS, CCRSA)
Starting date	March 2010
Contact information	Center for Aphasia Research and Treatment, Rehabilitation Institute of Chicago, Chicago, Illinois, USA Contact: Leora R Cherney PhD (Principal investigator): Tel: +1 312 238 6163     Email: lcherney@ric.org
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