Table 2.
Supportive care and treatment in children with severe malaria according to AKI status
| Severe malarial anemia (n = 219) | Cerebral malaria (n = 260) | |||||
|---|---|---|---|---|---|---|
| No AKI (n = 164) | AKI (n = 55) | p value | No AKI (n = 147) | AKI (n = 113) | p value | |
| Supportive care | ||||||
| Oxygen | 22 (6.7) | 7 (12.7) | 0.160 | 71 (48.3) | 76 (67.3) | 0.002 |
| Antipyretics | 161 (98.2) | 53 (96.4) | 0.437 | 138 (93.9) | 104 (92.0) | 0.562 |
| Medications | ||||||
| Quinine | 127 (77.4) | 44 (80.0) | 0.691 | 131 (89.1) | 99 (87.6) | 0.707 |
| Artesunate/artemether | 55 (33.5) | 16 (29.1) | 0.619 | 43 (29.3) | 39 (34.5) | 0.420 |
| Anticonvulsants | 1 (0.6) | 2 (3.6) | 0.156 | 109 (74.2) | 96 (85.0) | 0.034 |
| Furosemide | 32 (19.5) | 11 (20.0) | 0.937 | 9 (6.1) | 26 (23.0) | < 0.0001 |
| Bolus dextrose | 28 (17.1) | 28 (50.9) | < 0.0001 | 132 (89.8) | 91 (80.5) | 0.034 |
| Intravenous fluids | 12 (7.3) | 5 (9.1) | 0.671 | 24 (16.3) | 32 (28.3) | 0.020 |
| 0.9% saline | 10 (6.1) | 4 (7.3) | 0.754 | 18 (12.2) | 24 (21.2) | 0.051 |
| Ringer’s lactate | 0 (0.0) | 0 (0.0) | – | 2 (1.4) | 4 (3.5) | 0.246 |
| 10% dextrose | 0 (0.0) | 0 (0.0) | – | 4 (2.7) | 2 (1.8) | 0.700 |
| Bicarbonate | 0 (0.0) | 0 (0.0) | – | 0 (0.0) | 1 (0.9) | 0.435 |
| Darrow’s | 0 (0.0) | 1 (1.8) | 0.251 | 1 (0.7) | 0 (0.0) | 1.000 |
| Albumin | 2 (1.2) | 0 (0.0) | 1.000 | 2 (1.4) | 4 (3.5) | 0.408 |
| Blood transfusion | 164 (100.0) | 55 (100.0) | – | 68 (46.3) | 81 (71.7) | < 0.0001 |
Data presented as n (%) and compared using Pearson’s chi-square or Fisher’s exact, as appropriate