Table 2.
Overall survival and penis cancer-specific survival estimates with clinicopathological characteristics according to LVI
| Overall survival,% | Penile carcinoma-specific survival,% | |||
|---|---|---|---|---|
| Group | 3-Year Probability (SEM) | P | 3-Year Probability (SEM) | P |
| All patients | < 0.001 | < 0.001 | ||
| LVI absent | 68.1(2.3) | 85.3(1.9) | ||
| LVI present | 48.6(4.6) | 68.5(4.8) | ||
| T stage | ||||
| Tx + Ta + T1 | 0.007 | < 0.001 | ||
| LVI absent | 73.3(2.9) | 90.7(2.0) | ||
| LVI present | 53.7(9.6) | 65.4(10.3) | ||
| T2 | 0.011 | 0.163 | ||
| LVI absent | 66.3(4.5) | 80.4(4.5) | ||
| LVI present | 42.1(8.8) | 75.4(8.3) | ||
| T3 | 0.368 | 0.584 | ||
| LVI absent | 48.0(7.2) | 69.9(7.0) | ||
| LVI present | 54.1(6.4) | 69.0(7.0) | ||
| T4 | 0.067 | 0.207 | ||
| LVI absent | 66.7(20.8) | 85.7(11.7) | ||
| LVI present | – | – | ||
| Lymph nodes status | ||||
| Nx | 0.826 | 0.515 | ||
| LVI absent | 44.5(17.7) | 88.9(10.5) | ||
| LVI present | 57.1(18.7) | 66.7(19.2) | ||
| N0 | < 0.001 | 0.040 | ||
| LVI absent | 72.9(2.4) | 91.0(1.7) | ||
| LVI present | 56.7(6.0) | 84.3(5.0) | ||
| N1-N3 | 0.145 | 0.227 | ||
| LVI absent | 44.4(6.5) | 54.7(7.2) | ||
| LVI present | 35.9(7.5) | 48.1(8.6) | ||
| Grade | ||||
| G1 | 0.001 | < 0.001 | ||
| LVI absent | 76.4(3.7) | 97.1(1.4) | ||
| LVI present | 45.0(12.7) | 50.9(14.8) | ||
| G2 | 0.001 | 0.014 | ||
| LVI absent | 67.0(3.2) | 81.1(3.0) | ||
| LVI present | 49.5(6.6) | 70.6(6.8) | ||
| G3 + G4 | 0.181 | 0.408 | ||
| LVI absent | 54.7(6.4) | 75.8(5.7) | ||
| LVI present | 47.3(7.8) | 70.9(7.7) | ||
| Distant metastasis | ||||
| No | < 0.001 | < 0.001 | ||
| LVI absent | 69.6(2.3) | 87.2(1.9) | ||
| LVI present | 49.9(4.8) | 70.8(4.9) | ||
| Yes | 0.286 | 0.208 | ||
| LVI absent | – | – | ||
| LVI present | 35.6(15.6) | 45.5(17.6) | ||
| Regional lymph nodes removed | ||||
| No | < 0.001 | < 0.001 | ||
| LVI absent | 68.3(2.5) | 88.6(1.9) | ||
| LVI present | 45.6(5.9) | 67.6(6.7) | ||
| Yes | 0.016 | 0.137 | ||
| LVI absent | 67.9(5.4) | 74.6(5.2) | ||
| LVI present | 53.3(7.4) | 69.9(6.9) | ||
| Surgery | ||||
| Non-radical surgery | < 0.001 | < 0.001 | ||
| LVI absent | 68.7(2.3) | 85.4(2.0) | ||
| LVI present | 52.0(4.8) | 72.1(4.9) | ||
| Radical surgery | 0.037 | 0.002 | ||
| LVI absent | 50.8(16.5) | 87.1(8.6) | ||
| LVI present | 13.7(11.8) | 26.7(15.6) | ||
LVI lymphovascular invasion; SCCP squamous cell carcinoma of the penis; SEM standard error of mean
Significant values in bold, “-” = no data