Table 4.
Multivariate Cox regression analyses predicting overall survival and penis cancer-specific survival
| Variables | Overall survival | Penile carcinoma-specific survival | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | P | Hazard Ratio | 95% CI | P | |
| T stage | 0.066 | 0.420 | ||||
| Tx + Ta + T1 | 1.000 | Referent | – | 1.000 | Referent | – |
| T2 | 1.405 | 1.016–1.945 | 0.040 | 1.219 | 0.701–2.118 | 0.483 |
| T3 | 1.528 | 1.046–2.230 | 0.028 | 1.302 | 0.709–2.391 | 0.395 |
| T4 | 2.134 | 0.839–5.428 | 0.112 | 2.786 | 0.797–9.740 | 0.109 |
| Lymph nodes status | < 0.001 | < 0.001 | ||||
| Nx | 1.000 | Referent | – | 1.000 | Referent | – |
| N0 | 0.522 | 0.253–1.079 | 0.079 | 0.361 | 0.104–1.247 | 0.107 |
| N1-N3 | 1.290 | 0.596–2.791 | 0.518 | 1.645 | 0.465–5.820 | 0.440 |
| Grade | 0.068 | 0.171 | ||||
| G1 | 1.000 | Referent | – | 1.000 | Referent | – |
| G2 | 1.057 | 0.750–1.488 | 0.752 | 1.342 | 0.691–2.607 | 0.386 |
| G3 + G4 | 1.484 | 1.002–2.197 | 0.049 | 1.913 | 0.924–3.959 | 0.080 |
| Distant metastasis | 1.796 | 1.042–3.095 | 0.035 | 2.938 | 1.484–5.815 | 0.002 |
| regional lymph nodes removed | 0.457 | 0.314–0.666 | < 0.001 | 0.734 | 0.424–1.270 | 0.269 |
| Surgery | 1.768 | 1.063–2.940 | 0.028 | 1.992 | 0.947–4.192 | 0.069 |
| LVI | 1.403 | 1.017–1.936 | 0.039 | 1.324 | 0.798–2.198 | 0.277 |
SCCP squamous cell carcinoma of the penis; LVI lymphovascular invasion; CI confidence intervals
Significant values in bold