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. 2019 May 20;20:99. doi: 10.1186/s13059-019-1701-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effects of covariates on circRNA expression. a Distribution of the mean expression of each circRNA in exonic, intronic, and intergenic regions. The black dashed line indicates the cumulative data fraction. b Differential circRNA expression detected as a function of age of death. The dots in red indicate significantly differentially expressed circRNAs (FDR ≤ 0.05). c CDR1as expression with age of death is plotted. d Boxplot for the expression of gender-related circRNA (chr9:44106654|44114921) from a pseudogene, ANKRD20A7P. The center line denotes the median, the limits are the interquartile range (IQR), the whiskers are 1.5× the IQR, and outliers are shown as black dots