Fig. 4.

Distribution of the identified circQTL SNPs. a Distance distribution of the most strongly associated circQTL SNPs for each circRNA (max-circQTL) to their nearest back-spliced site. For internal max-circQTL SNPs, the distance was calculated by the ratio of the distance between the SNP and the 3′ to 5′ back-splicing site. b Comparison of the distributions of sequence-defined elements between pruning max-circQTL SNPs and non-circQTL SNPs. c Enrichment of max-circQTL SNPs among sequence-defined elements. The dashed horizontal line indicates an FDR = 0.01, and the dashed vertical line indicates an odds ratio (OR) = 1, two-tailed FET