Table 2.
Identified virulence factors and antigen proteins in MTB
| ORF | Accession number | Annotated gene | Our annotation | Antigen protein |
|---|---|---|---|---|
| Rv2707 | NP_217223.1 | rpoS | RNA polymerase sigma factor rpoS | NO |
| Rv0674 | NP_215188.1 | pspA | Phage shock protein pspA | YES |
| Rv1518 | NP_216034.1 | wcaA | Colanic acid biosynthesis glycosyl transferase wcaA | YES |
| Rv0498 | NP_215012.1 | tagE | alpha-glucosyltransferase | YES |
| Rv1893 | NP_216409.1 | prm1 | Plasma membrane fusion protein prm1 | YES |
| Rv0546c | NP_215060.1 | gloA | Lactoylglutathione lyase | YES |
| Rv1505c | NP_216021.1 | epsM | acetyltransferase epsM | YES |
| Rv0049 | NP_214563.1 | ygaZ | Inner membrane protein ygaZ | YES |
| Rv2694c | NP_217210.1 | artP | Arginine transport ATP-binding protein artP | NO |
| Rv2365c | NP_216881.1 | ydbL | Protein ydbL | YES |
| Rv2327 | NP_216843.1 | slyA | Transcriptional regulator slyA | YES |
| Rv2751 | NP_217267.1 | yktD | adenosyl-methionine-dependent methyltransferase yktD | YES |
Twelve new virulence factors were found in MTB in this study. The antigen proteins could be applied to vaccine development for the prevention of MTB