Table 1.

Morphologic, Immunophenotypic, and Molecular Genetic Characteristics of 3 Patients With Primary CNS A-DLBCL

	Cell of Origin		Immunohistochemistry									FISH			Mutation Statuses
Patient	Hans	Choi	CD5	CD30	Ki-67	BCL2	MYC	P53	RELA	RELB	c-Rel	MYC	BCL2	BCL6	TP53	MYD88	CD79B	CARD11	EZH2
															(exon 5–10)	(exon 5)	(exon 5)	(exon 5–9)	(exon 16)
1	GCB	GCB	–	+	90%	+	+	All negative	+	+	+	extracopy	extracopy	extracopy	WT	L265P	WT	WT	WT
2	Non-GCB	Non-GCB	–	–	80%	+	+	Variable>50%	+	+	+	extracopy	extracopy	extracopy	WT	L265P	WT	WT	WT
3	Non-GCB	Non-GCB	–	–	70%	+	+	Diffuse	+	+	–	extracopy	no	split	R273C	L265P	WT	WT	WT

Abbreviations: GCB germinal center B cell, WT wild type