Table 1.

Significant differences in Ingenuity canonical signaling pathways between HPG and PYS

Signaling pathways	HPG (d3) (total 78)	PYS (d3) (total 424)	PYS (d7) (total 161)
Diphthamide biosynthesis	−2.09	Nil	Nil
S-adenosyl-L-methionine biosynthesis	−2.09	− 0.874	Nil
Unfolded protein response	−2.01	− 0.321	− 1.53
Role of CHK proteins in cell cycle checkpoint	−1.98	Nil	Nil
Cell cycle: G1/S checkpoint regulation	−1.86	0	Nil
Role of BRCA1 in DNA damage response	−1.7	−2.4	Nil
Cyclins and cell cycle regulation	−1.7	−0.497	Nil
Folate transformations I	−1.62	−0.456	Nil
Neuroprotective role of THOP1 in Alzheimer’s disease	−1.39	0	−0.354
Mismatched repair in eukaryotes	−1.37	−0.272	Nil
GADD45 signaling	−1.3	−0.654	Nil
Methylglyoxal degradation III	−1.3	−0.224	−1.05
DNA damage-induced 14–3-3σ signaling	−1.3	−0.224	Nil
Cell cycle: G2/M DNA damage checkpoint regulation	−0.906	−2.13	Nil
Hereditary breast cancer signaling	−1.24	−1.76	Nil
VDR/RXR activation	Nil	−1.54	Nil
Lipoate salvage and modification	Nil	−1.33	Nil
Inositol pyrophosphates biosynthesis	Nil	−1.3	Nil
CDK5 signaling	Nil	0	−1.9
Antigen presentation pathway	Nil	−0.583	−1.83
Cardiac β-adrenergic signaling	−0.325	0	−1.5
Induction of apoptosis by HIV1	Nil	0	−1.44
Mitotic roles of Polo-like kinases	−0.787	−0.711	−1.38
Dopamine-DARPP32 feedback in cAMP signaling	Nil	0	−1.33
Ephrin B signaling	Nil	−0.594	−1.3
CPCR-mediated integration of enteroendocrine signaling exemplified by an L cell	Nil	−0.351	−1.3

The total number of affected pathways was presented in each group (n = 3, three separate RNA samples). The p value was calculated by t-test as compared with the baseline control at day 0, and it was presented in a log₁₀ value (− 1.30 = 0.05). Nil: not in the list of affected pathways