Table 3.
Genotype analysis of HNF1A gene SNPs
| Controls, n | Diabetes, n | OR (95% CI) | P | |
|---|---|---|---|---|
| I27L rs1169288 (%) | ||||
| *Co-dominant Wild type GG | 105 | 146 | ||
| Heterozygous GT | 120 | 233 | 1.02 (0.57–1.78) | 0.984 |
| Homozygous TT | 38 | 110 | 1.71 (1.25–3.46) | 0.024 |
| Dominant (GT + TT/GG) | 158 vs 105 | 343 vs 146 | 1.68 (1. 21-2.13) | 0.035 |
| Recessive (TT/GT + GG) | 38 vs 225 | 110 vs 379 | 1.56 (1. 14-2.57) | 0.048 |
| S487 N rs2464196 (%) | ||||
| *Co-dominant Wild type CC | 102 | 188 | ||
| Heterozygous CT | 121 | 210 | 0.58 (0.35–1.39) | 0.471 |
| Homozygous TT | 40 | 91 | 1.25 (0.57–2.75) | 0.638 |
| Dominant (CT + TT/CC) | 161 vs 102 | 301 vs 188 | 1.01 (0.74–1.38) | 0.938 |
| Recessive (TT/CT + CC) | 40 vs 223 | 91 vs 398 | 1.27 (0.84–1.91) | 0.241 |
| A98V rs1800574 (%) | ||||
| *Co-dominant Wild type CC | 208 | 411 | ||
| Heterozygous CT | 52 | 64 | 1.26 (0.48–3.29) | 0.676 |
| Homozygous TT | 3 | 14 | 1.35 (0.95–3.54) | 0.027 |
| Dominant model (CT + TT/CC) | 55 vs 208 | 78 vs 411 | 0.71 (0.48–1.05) | 0.089 |
| Recessive model (TT/CT + CC) | 3 vs 260 | 14 vs 475 | 2.55 (0.72–8.97) | 0.130 |
*Co-dominat model was compared wild type, homozygous variant and heterozygous variant were compared
DM Diabetes mellitus, OR odds ratio, CI confidence interval
Data are shown as mean ± standard deviation (means ± SD) and percentage (%)
Bold represents the significant p-values
Categorical variables were analyzed with Chi-square test or Fisher’s exact test, where appropriate
Multiple logistic regression analysis and Fisher’s exact test were tested using models: dominant (major allele homozygotes vs heterozygotes + minor allele homozygotes), recessive (major allele homozygotes + heterozygotes vs minor allele homozygotes) and codominant (major allele homozygotes vs heterozygote and minor allele homozygotes vs major allele homozygotes)