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. 2019 May 20;17:165. doi: 10.1186/s12967-019-1917-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Characterization of NK cells in a murine esophageal cancer model. a Scheme of 4-NQO-induced carcinogenesis in C57BL/6 mice. b Average body weight of mice in control group and 4-NQO group before sacrifice. c Histological analysis of 4NQO-induced esophageal lesions in mice (×200). d Phenotypic analysis of splenocytes isolated from control group (n = 8) or 4-NQO group (n = 17) using flow cytometry. Flow cytometric analysis of Tim-3⁺ NK cells (e) and CD69⁺ NK cells (f) in splenocytes from control group (n = 5) or 4-NQO group (n = 10). g Relative mRNA levels of TNF-α and Tim-3 in esophageal tumor tissues and adjacent normal tissues from 4-NQO-induced mice (left panel) and a strong correlation between TNF-α and Tim-3 expression in esophageal tumor tissues (right panel). *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant