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. 2019 May 20;17:165. doi: 10.1186/s12967-019-1917-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Tim-3⁺ NK cells are significantly associated with pathological parameters for poor prognosis in patients with primary esophageal cancer. The frequency of NK cells according to tumor invasion, lymph node metastasis and pathological stage in PBMC (a) and TIL (b), respectively. The frequency of Tim-3⁺ NK cells according to tumor invasion, lymph node metastasis and pathological stage in PBMC (c) and TIL (d), respectively. *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant