Table 1. Laboratory data follow-up according to the patient’s age (years).
| Initial (20 years) |
After PTX (22 years) |
At diagnosis (24 years) |
Follow-up (25 years) |
Reference values | |
|---|---|---|---|---|---|
| Blood | |||||
| Creatinine (mg/dL) | 1.67 | 2.25 | 3.2 | 3.8 | 0.4 – 1.3 |
| Urea (mg/dL) | 39 | 49 | 48 | 87 | 15 – 45 |
| Sodium (mEq/L) | 141 | 139 | 147 | 146 | 135 – 145 |
| Potassium (mEq/L) | 4.3 | 4.2 | 5.7 | 4.2 | 3.9 – 5.0 |
| Magnesium (mg/dL) | – | – | 1.3 | 1.67 | 1.8 – 2.5 |
| Calcium (mg/dL) | 8.9 | 8.5 | 9.2 | 10.4 | 8.8 – 11.0 |
| Phosphorus (mg/dL) | 2.6 | 3.35 | 3.38 | 3.6 | 2.5 – 4.8 |
| Bicarbonate (mmol/L) | 22.4 | – | 26.6 | – | 22 – 26 |
| Intact PTH (pg/mL) | 227 | 374 | 599 | 154 | 12 – 72 |
| 25-OH-Vitamin D (ng/mL) | 23 | 28 | 44 | 26 | 30 – 100 |
| 1.25-OH-Vitamin D (pg/mL) | – | – | 65.3 | – | 15.2 – 90.1 |
| Uric acid (mg/dL) | 8.5 | 13.4 | 13.0 | 8.4 | 2.5 – 7.0 |
| Albumin (g/dL) | 4.3 | – | 4.4 | – | 3.5 – 5.2 |
| Glucose (mg/dL) | 94 | 94 | 101 | 100 | 60 – 99 |
| Alkaline phosphatase (u/L) | 68 | 84 | 59 | – | 40 – 129 |
| Urine | |||||
| 24-hour | |||||
| Urinary volume (mL) | 2,900 | 2,970 | 3,020 | 2,800 | < 3,000 |
| Proteinuria (mg/24h) | 1,682 | 2,480 | 2,861 | – | < 150 |
| Albuminuria (mg/24h) | – | – | – | 2,765 | < 30 |
| RBP (mg/L) | 0.3 | – | – | – | ≤ 0.4 |
| Calcium (mg/24h) | 315 | – | 306 | 145 | < 200 |
| Sodium (mEq/24h) | – | – | 127 | 112 | 43 – 220 |
| Potassium (mEq/24h) | – | – | 39 | 16 | 25 – 125 |
| Magnesium (mg/24h) | – | – | 112 | 151 | 73 – 122 |
| FEMg2+ (%) | – | – | 15.9 | 19.4 | 2 – 4 |
| Phosphorus (mg/24h) | 986 | – | 984 | 589 | 340 – 1,000 |
| Citrate (mg/24h) | – | – | 39 | 60 | 320 – 1,240 |
| Oxalate (mg/24h) | – | – | 22 | 5.6 | 7 – 44 |
| Uric acid (mg/24h) | 142 | – | 256 | 97 | 250 – 750 |
| Spot | |||||
| pH | – | 6.0 | 6.0 | 6.0 | 4.5 – 8 |
| Glucose | Negative | Negative | Negative | Negative | Negative |
| Red blood cells (/HPF) | 2 | 6 | 2 – 4 | 2 | < 5 |
| Leukocyturia (/HPF) | Numerous | 25 | 20 | Numerous | < 5 |
| Proteinuria | + | ++ | ++ | ++ | Negative |
| β2-microglobulin (ng/mL) | 8.3 | – | 4.01 | – | ≤ 300 |
PTX = parathyroidectomy; FEMg2+ = fractional excretion of magnesium; RBP = retinol-binding protein.