Table 4. Descriptive summary of UGE24 and inhibition of glucose reabsorption.
Parameter (units) | Total daily dose 5 mg | Total daily dose 15 mg | |||
---|---|---|---|---|---|
Ertugliflozin 2.5 mg BID | Ertugliflozin 5 mg QD | Ertugliflozin 7.5 mg BID | Ertugliflozin 15 mg QD | ||
UGE24, g | n | 20 | 20 | 21 | 23 |
Geometric mean | 57.1 | 52.5 | 58.6 | 57.6 | |
%CV | 31 | 34 | 28 | 28 | |
Inhibition of glucose reabsorption, % | n | 20 | 20 | 21 | 23 |
Arithmetic mean | 40.3 | 38.5 | 42.0 | 40.6 | |
%CV | 27 | 29 | 26 | 26 |
Values are geometric mean and geometric %CV for UGE24; or arithmetic mean and arithmetic %CV for inhibition of glucose reabsorption. BID = twice daily; %CV = percent coefficient of variation; n = number of subjects contributing to the summary statistics; QD = once daily; UGE24 = urinary glucose excretion over 24 hours.