Table 4.

Univariate and multivariate survival analyses of clinicopathologic factors, GPER and Ezrin expression.

	Univariate model			Multivariate model
	P*	OR	95% CI for OR	P**	HR	β	95% CI for HR
Any event
Age	0.836	0.997	0.974–1.022
Site (left vs right)	0.527	1.182	0.704–1.986
Nuclear grade (G2 vs G3)	0.001	0.203	0.083–0.500	0.001	0.240	−1.425	0.104–0.566
Tumor size	0.088	1.146	0.980–1.340
LNM (no vs yes)	<0.001	0.369	0.216–0.629	0.072	0.621	−0.476	0.370–1.043
TNM (I/II vs III)	<0.001	0.187	0.101–0.345	0.002	0.436	−0.831	0.257–0.740
GPER (low vs high)	<0.001	0.173	0.096–0.313	<0.001	0.393	−0.933	0.246–0.629
Ezrin (low vs high)	<0.001	0.274	0.156–0.479	0.141	0.697	−0.361	0.431–1.127
Death
Age	0.489	1.009	0.983–1.036
Site (left vs right)	0.634	0.871	0.493–1.538
Nuclear grade (G2 vs G3)	0.002	0.153	0.046–0.511	0.007	0.201	−1.606	0.063–0.644
Tumor size	0.021	1.215	1.030–1.434	0.023	1.168	0.156	1.022–1.336
LNM (no vs yes)	<0.001	0.218	0.118–0.402	0.064	0.533	−0.629	0.274–1.036
TNM (I/II vs III)	<0.001	0.119	0.063–0.228	0.002	0.359	−1.023	0.190–0.679
GPER (low vs high)	<0.001	0.259	0.142–0.473	0.025	0.528	−0.639	0.301–0.924
Ezrin (low vs high)	<0.001	0.266	0.147–0.483	0.073	0.595	−0.519	0.337–1.336
Relapse event
Age	0.197	0.977	0.943–1.012
Site (left vs right)	0.808	1.094	0.530–2.258
Nuclear grade (G2 vs G3)	0.049	0.230	0.053–0.994	0.050	0.239	−1.433	0.057–1.001
Tumor size	0.950	1.007	0.881–1.250
LNM (no vs yes)	0.005	0.336	0.158–0.716	0.209	0.569	−0.564	0.236–1.372
TNM (I/II vs III)	<0.001	0.235	0.111–0.498	0.023	0.368	−0.998	0.156–0.871
GPER (low vs high)	<0.001	0.229	0.108–0.485	0.004	0.329	−1.113	0.153–0.704
Ezrin (low vs high)	0.019	0.414	0.199–0.863	0.752	0.884	−0.124	0.410–1.904
Distant event
Age	0.301	0.985	0.957–1.014
Site (left vs right)	0.529	0.823	0.448–1.511
Nuclear grade (G2 vs G3)	0.010	0.201	0.060–0.676	0.005	0.184	−1.695	0.056–0.602
Tumor size	0.075	1.165	0.985–1.379
LNM (no vs yes)	<0.001	0.310	0.165–0.585	0.070	0.525	−0.644	0.262–1.053
TNM (I/II vs III)	<0.001	0.174	0.090–0.334	0.022	0.449	−0.801	0.227–0.889
GPER (low vs high)	<0.001	0.124	0.063–0.242	0.001	0.346	−1.061	0.182–0.658
Ezrin (low vs high)	<0.001	0.108	0.054–0.214	0.001	0.320	−1.139	0.162–0.631

*Logistic regressive model; **Cox regression model.

CI, confidence interval; HR, hazard ratio; LNM, lymph node metastasis; OR, odds ratio.