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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Neurobiol Aging. 2019 Jan 30;77:87–93. doi: 10.1016/j.neurobiolaging.2019.01.023

Figure 2. The PDZ1 domain of Par3 is necessary for its effect on BACE1 trafficking.

Figure 2.

(a) N2a cells were transfected with indicated constructs together with hBACE1-FLAG. Cells were immunostained for FLAG (red) and TGN38 (blue). Venus (green) indicates positive cells. (b) Quantification for percentages of BACE1 colocalized with TGN. Data were expressed as Mean ± SEM with one way ANOVA, *p<0.05; ** p<0.01; *** p<0.001. N (cells) = 15 (Luciferase shRNA), 15 (Par3 shRNA), 15 (Par3b), 15 (Par3c), 19 (Par3c-B), 23 (Par3c-C), from 5 independent experiments. Scale bar: 10μm.