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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Neurobiol Aging. 2019 Jan 30;77:87–93. doi: 10.1016/j.neurobiolaging.2019.01.023

Figure 6. Loss of Par3 increases the convergence of internalized APP with BACE1 in axons.

Figure 6.

(a) Hippocampal neurons were transfected with WT APP695, BACE1-GFP and the indicated shRNA constructs. 72 hours after transfection, internalized APP (60 min) was immunostained (red) to visualize colocalization of internalized APP and BACE1 in axons. Scale bar: 10 μm.

(b) Quantification of colocalization of internalized APP with BACE1 in axons. N (cells) = 8 (Luciferase shRNA), 13 (Par3 shRNA), from 3 independent experiments. Data were expressed as Mean ± SEM with Student’s t test: **p<0.01.