Table 3.

Comparison of differences in manifestations of CKD and cardiac hypertrophy between male and female mice fed with a normal Pi diet

	Male	Female	P-value
Animal number	4	5
BUN (mg/dl)	36.3 ± 1.3	31.7 ± 1.9	<0.01
Cr (mg/dl)	0.34 ± 0.09	0.31 ± 0.07	<0.05
CrCl (ml/min/100g BW)	0.69 ± 0.04	0.77 ± 0.06	<0.05
Plasma Pi (mg/dl)	8.21 ± 0.32	7.62 ± 0.24	<0.05
Plasma Ca (mg/dl)	9.21 ± 0.10	9.11 ± 0.07	>0.05
Plasma PTH (pg/ml)	321 ± 52	291 ± 42	>0.05
Plasma 1,25-(OH)2D3 (pg/ml)	70.4 ± 6.2	65.5 ± 5.3	>0.05
Plasma FGF23 (pg/ml)	2016 ± 330	1757 ± 139	>0.05
Heart weight/body weight (mg/g)	5.69 ± 0.32	5.28 ± 0.31	0.08

Data presented in Table 3 are derived from mice injected cisplatin and treated with normal Pi diet presented in Table 2 and were shown as means ± SD at 20 weeks. The statistical significance between male and female mice was analyzed by unpaired Student t-test