. Author manuscript; available in PMC: 2019 May 21.

Published in final edited form as: Lab Invest. 2018 Jun 1;98(8):1105–1121. doi: 10.1038/s41374-018-0063-2

Table 4.

Comparison of differences in manifestations of CKD and cardiac hypertrophy between male and female mice fed with a high Pi diet

	Male	Female	P-value

Animal number	4	4
BUN (mg/dl)	48.4 ± 3.4	39.5 ± 2.4	<0.05
Cr (mg/dl)	0.61 ± 0.04	0.43 ± 0.03	<0.01
Cr_Cl (ml/min/100 g BW)	0.51 ± 0.04	0.64 ± 0.05	<0.05
Plasma Pi (mg/dl)	9.04 ± 0.71	7.78 ± 0.65	0.058
Plasma Ca (mg/dl)	8.97 ± 0.75	9.06 ± 0.79	>0.05
Plasma PTH (pg/ml)	516 ± 49	390 ± 23	<0.01
Plasma 1,25-(OH)₂D₃ (pg/ml)	43.1 ± 3.8	56.4 ± 4.9	<0.05
Plasma FGF23 (pg/ml)	2700 ± 325	2081 ± 196	<0.05
Heart weight/body weight (mg/g)	6.61 ± 0.42	5.68 ± 0.29	<0.05

Data presented in Table 4 are derived from mice injected cisplatin and treated with high Pi diet presented in Table 2 and were shown as means ± SD at 20 weeks. The statistical significance was analyzed by unpaired Student t-test