Table 5.

Comparison of differences in responses to exogenous Klotho protein between male and female CKD mice fed with a high Pi diet

	Vehicle			Cisplatin
	Male	Female	P-value	Male	Female	P-value
Animal number	5	5		4	5
BUN (mg/dl)	22.3 ± 1.2	20.9 ± 1.1	>0.05	31.2 ± 2.2	22.9 ± 1.5	<0.01
Cr (mg/dl)	0.14 ± 0.03	0.11 ± 0.02	>0.05	0.27 ± 0.03	0.21 ± 0.01	<0.01
CrCl (ml/min/100g BW)	1.01 ± 0.06	0.94 ± 0.05	0.08	0.75 ± 0.03	0.85 ± 0.04	<0.05
Plasma Pi (mg/dl)	6.92 ± 0.48	6.67 ± 0.31	>0.05	7.41 ± 0.27	6.38 ± 0.21	<0.01
Plasma Ca (mg/dl)	9.31 ± 0.45	9.23 ± 0.32	>0.05	9.12 ± 0.45	9.19 ± 0.32	>0.05
Plasma PTH (pg/ml)	165 ± 16	147 ± 10	>0.05	303 ± 36	290 ± 19	>0.05
Plasma 1,25-(OH)2D3 (pg/ml)	78.2 ± 6.4	89.8 ± 11.7	0.087	27.1 ± 2.7	34.6 ± 3.6	<0.05
Plasma FGF23 (pg/ml)	155 ± 78	140 ± 45	>0.05	1308 ± 219	883 ± 102	<0.01
Heart weight/body weight (mg/g)	5.13 ± 0.29	4.89 ± 0.14	>0.05	5.23 ± 0.39	5.11 ± 0.21	>0.05

Data were presented as means ± SD at 20 weeks. The statistical significance was analyzed by unpaired Student t-test