Table 1 |.
Potential reference cell systems for epigenomic analysis
| Organ system | Tissue progenitor | Differentiated cell | Altered disease state |
|---|---|---|---|
| Embryo | Embryonic stem cells | ||
| Haematopoietic | CD34+ | Polymorphonuclear leukocytes, lymphoid, etc. | Acute myelogenous leukemia, Acute lymphoblastic leukemia, Chronic myelogenous leukemia, Myelodysplastic syndrome |
| Breast | CD24+and/or CD44+ | Myoepithelial, luminal, fibroblasts | Breast cancer |
| Liver | Oval cell | Hepatocytes, stromal cells | Cirrhosis, viral disease, Hepatocellular carcinoma |