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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Mol Endocrinol. 2019 Feb 1;62(2):R129–R143. doi: 10.1530/JME-18-0165

Figure 1. A proposed framework for molecular mechanisms underlying sex differences in body weight control.

Figure 1.

The Sry gene in the Y chromosome determines gonadal development and therefore the levels of sex hormones. The X chromosome dosage adds the risk of obesity in females; some X-linked genes have been implicated in the regulation of energy balance. Sex hormones are involved in the regulation of body weight balance in both sexes. In addition, other factors (autosome-encoded factors that are not sex hormones/receptors) contribute to the sex differences in body weight control. These three categories of factors are integrated through their reciprocal interactions to ultimately determine the sex differences in body weight balance.