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. 2019 Apr 27;1(5):199–205. doi: 10.1253/circrep.CR-18-0012

Figure 3.

Figure 3.

Elastin fragmentation of wild-type (WT) and fibrillin-1 (FBN1)mgR/mgR correlated with ascending aortic diameter. (A,B) Representative elastin autofluorescence imaging of elastin fragmentation from WT and FBN1mgR/mgR mice at the largest ascending aortic diameter. Green line, 100 µm. (C) Elastin fragmentation quantified. (D) Elastin fragmentation vs. circumferential strain (R2=0.628, P=0.004). (E,F) Elastin breaks vs. aortic diameter in (E) systole (R2=0.397, P=0.038) and (F) diastole (R2=0.515, P=0.013). n=3, male WT, male mgR, female WT. n=2, female mgR.