Table.

Characteristics of WT and FBN1^mgR/mgR Mice

Sex / Genotype	n	Age at ultrasound (days)	Body weight (g)	SBP (mmHg)	Pulse rate (beats/min)	AoDs (mm)†	AoDd (mm)†	AoDs–AoDd (mm)‡
Male
WT	8	74.8±1.0	25.7±0.5	147±7	506±23	1.50±0.05	1.29±0.05***	0.21±0.02
FBN1mgR/mgR	8	74.8±1.0	26.2±0.8	139±18	524±31	2.35±0.13	2.24±0.15**	0.11±0.04*
Female
WT	5	74.7±1.3	20.5±0.7	137±9	547±58	1.42±0.03	1.23±0.04***	0.21±0.01
FBN1mgR/mgR	7	75.2±1.2	20.8±0.8	125±13	443±23	1.64±0.07	1.57±0.08**	0.07±0.02*

Data given as mean±SEM. P>0.05 between WT vs. FBN1^mgR/mgR by Student’s t-test. *P<0.05 WT vs. FBN1^mgR/mgR. **P<0.01, ***P<0.001, AoDs vs. AoDd. Male and female FBN1 WT and FBN1^mgR/mgR mice were aged to 11 weeks. Body weight was measured before ultrasonography. SBP and pulse rate were measured for 3 consecutive days using a tail cuff-based technique. No measurements were significantly different between WT and FBN1^mgR/mgR within sex. ^†Male mice: WT P<0.001, FBN1^mgR/mgR P=0.004; female mice: WT P<0.001, FBN1^mgR/mgR P=0.009. ^‡WT vs. FBN1^mgR/mgR: male mice, P=0.03; female mice, P=0.01. AoDd, aortic diameter in diastole; AoDs, aortic diameter in systole; FBN1, fibrillin-1; SBP, systolic blood pressure; WT, wild type.