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(a) Immuno-dominant epitopes of the VP1 protein of foot-and-mouth disease (FMD) virus. (b) A tandem-repeat multiple-epitope gene (polytope). (c) Construction of the Polytope/interleukin-2 (IL-2)/FcIgG synthetic gene. (d) Gene fragments isolated from the polytope-IL-2-FcIgG fusion gene that were used to construct recombinant vaccines
