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Up-regulation of FOXO1 in IF-INS-1 cells impaired insulin secretion function. (A) Western blot images for FOXO1 and β-actin, showing doxycycline (DOX) induced high expression of FOXO1 in IF-INS-1 cells, but not in INS-1 cells. (B) The morphological changes of cells were observed under high power microscope, and the cells do not vary greatly in size and shape among groups
