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Oxidative stress through the stimulation of the endothelial NF-ĸB--iNOS--NO pathway and upregulation of homocysteine; eNOS: endothelial nitric oxide synthase, iNOS: inducible nitric oxide synthase, NADPH: nicotinamide adenine dinucleotide phosphate, NF-κB: nuclear factor kappa B, NO: nitric oxide, ROS: reactive oxygen species
