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After phagocytosis, L. pneumophila secretes AnkB which remains anchored to the vacuole via its farnesylation motif. AnkB then recruits the SCF E3 ubiquitin ligase complex through its F box. Increased ubiquitination of host proteins leads to increased free amino acid production and the accumulation of ubiquitin on the mature LCV to prevent fusion with lysosomes. See also Figure S5.
