Table 2.

Doses of various interventions in heart failure clinical trials

Trial	Drug	Target Daily Dose	Percent Reaching Target	Mean Daily Dose
V-HeFT [64]	Hydralazine/Isosorbide dinitrate	112.5/160mg	55%	270mg/136mg
CONSENSUS [65]	Enalapril	40mg	-	18.4mg
SOLVD Treatment [11]	Enalapril	20 mg	-	16.6mg
MERIT-HF [13]	Metoprolol CR/XL	200mg	64%	159mg
COPERNICUS [66]	Carvedilol	50mg	80%	45mg
COMET [67]	Metoprolol tartrate/ carvedilol	100/50mg	75%/78%	85mg/42 mg
RALES [14]	Spironolactone	25mg	-	26mg
CHARM-ALTERNATIVE [68]	Candesartan	32mg	-	23mg
A-HeFT [16]	Hydralazine/Isosorbide dinitrate	225/120 mg	68%	143mg/76mg
EMPHASIS [69]	Eplerenone	50mg	60.2%	39.1 mg