Table 4:
Target doses of heart failure medications from clinical trials [70]
| Starting dose (mg) | Target dose (mg) | |
|---|---|---|
| ACE Inhibitors | ||
| Captopril | 6.25 mg thrice a day | 50 mg thrice a day |
| Enalapril | 2.5 mg twice a day | 10–20 mg twice a day |
| Fosinopril | 5–10 mg daily | 40 mg daily |
| Lisinopril | 2.5–5.0 mg daily | 20–40 mg daily |
| Ramipril | 1.25–2.5 mg daily | 10 mg daily |
| Quinapril | 5 mg twice a day | 20 mg twice a day |
| Trandolapril | 1 mg daily | 4 mg daily |
| Angiotensin receptor blockers | ||
| Candesartan | 4–8 mg daily | 32 mg daily |
| Valsartan | 20–40 mg twice a day | 160 mg twice a day |
| Losartan | 25–50 mg daily | 50–150 mg daily |
| Angiotensin receptor neprilysin inhibitor | ||
| Sacubitril/valsartan | 49/51 mg twice a day | 97/103 mg twice a day |
| Beta-blockers | ||
| Bisoprolol | 1.25 mg daily | 10 mg daily |
| Carvedilol | 3.125 mg twice a day | 50 mg twice a day |
| Metoprolol succinate | 12.5–25 mg daily | 200 mg daily |
| Nebivolol | 1.25 mg daily | 10 mg daily |
| Mineralocorticoid-receptor antagonists | ||
| Eplerenone | 25 mg daily | 50 mg daily |
| Spironolactone | 12.5–25 mg daily | 25 mg daily/twice a day |
| If-channel blocker | ||
| Ivabradine | 5 mg twice a day | 7.5 mg twice a day |
| Isosorbide dinitrate and hydralazine | ||
| Hydralazine | 25–50 mg thrice a day | 100 mg thrice a day |
| Isosorbide dinitrate | 20–30 mg thrice a day | 40mg thrice a day |