Table 3.
Representative apoptotic biomarkers in NCI‐H446 cells after drug treatment
| Biomarkers | Fold change | Pathway | ||
|---|---|---|---|---|
| PSII/Control | Cur/Control | Com./Control | ||
| Bad | — | — | ↑(1.30) | Mitochondria |
| Bax | — | — | ↑(1.32) | |
| Bid | ↓(0.74) | — | — | |
| Bcl‐2 | — | — | ↑(1.36) | |
| Bad/Bcl‐2 | 1.1 | 1.1 | 1.0 | |
| CD40 | — | — | ↑(1.26) | Death receptor |
| CD40L | — | — | ↑(1.32) | |
| DR6 | — | — | ↑(1.27) | |
| Fas | — | — | — | |
| FasL | — | — | ↑(1.25) | |
| TNF‐α | ↑(1.21) | ↑(1.36) | ↑(1.33) | |
| IGFBP‐1 | — | — | ↑(1.35) | IGF/IGFBP |
| IGF‐I | ↓(0.74) | — | — | |
| p21 | — | — | ↑(1.20) | Cell cycle arrest |
| p27 | — | — | ↑(1.20) | |
The biomarkers in one color shading indicated that they acted in the same pathway