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. 2017 Nov 21;51(3):e12410. doi: 10.1111/cpr.12410

Figure 3.

Figure 3

Activation of extracellular‐signal‐regulated kinase 5 (ERK5) in beta cells is suppressed by BIX02189 in pregnant mice. A specific inhibitor of ERK5 activation, BIX02189 (BIX), was injected into the pregnant mice once per day from gestational day 1 to day 15 to suppress ERK5 signalling. The control pregnant mice received the same volume of saline and at the same frequency (saline). At gestational day 15, mouse islets were isolated and examined for levels of ERK5 and pERK5. A, Representative Western blotting for pERK5, ERK5 and GAPDH. B, Quantification of ERK5 levels (normalized to GAPDH). C, Quantification of pERK5 levels (normalized to ERK5). *P < .05. NS, no significance, n = 5.