Table 2.

Functional characterisation of the lncRNAs in IDD

LncRNAs	Expression	Functional role	Related genes	Reference
RP11‐296A18.3	Up	Proliferation matrix metalloproteinase	miR‐138 HIF1A	19
TUG1	Up	Senescence apoptosis ECM‐degrading	Wnt β‐catenin	52
HCG18	Up	Proliferation apoptosis	miR‐146a‐5p TRAF6	53
MALAT1	Down	Apoptosis inflammatory cytokines		55
SNHG1	Up	Proliferation	miR‐326	58
H19	Up	Senescence ECM‐degrading	miR‐22 LEF1	60
NEAT1	Up	ECM‐degrading	ERK/MAPK	62
linc‐ADAMTS5	Down	Aggrecan degradation	ADAMTS5	64