Table 1.
The caspase substrates of groups 1 and 2
| Substrates | Result | References |
|---|---|---|
| Nup50 | Disrupting interaction with other Nups | 45 |
| Nup96 | Disrupting interaction with other Nups | 45 |
| Nup93 | Disrupting interaction with other Nups | 45 |
| Nup153 | Impaired nuclear transport, redistribution of importins | 47, 136 |
| Nup214 | Impaired nuclear transport, redistribution of importins | 47 |
| POM121 | Disrupting interactions with other NPC proteins affecting NPC stability | 137 |
| RanBP2 (Nup358) | Increase of nuclear membrane permeability | 17 |
| Tpr | Increase of nuclear membrane permeability | 17 |
| Importin α | Downregulation of the nucleocytoplasmic protein transport and DNA synthesis | 16, 138 |
| Importin β | Inhibition of classical nuclear import | 16 |
| Lamins A/C ‐type | Disruption of nuclear integrity | 40, 41 |
| Lamins B‐type | Disruption of nuclear integrity | 40, 41 |
| Nuclear Mitotic Apparatus protein (NuMA) | Disruption of nuclear integrity | 51, 139 |
| LAP2β | Detachment of NE from chromatin | 38 |
| LBR | Detachment of NE from chromatin | 38 |
| C53/LZAP | Rupture of the NE | 54 |