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. 2019 May 21;16(5):e1002805. doi: 10.1371/journal.pmed.1002805

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© 2019 Conrad et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Drug dose trajectory of (A) ACE-I or ARB dose and (B) beta blocker, prescribed around the time of incident heart failure, in patients diagnosed from 2012–2014. Drug dose trajectory prescribed to patients with heart failure and reduced ejection fraction without contraindications or intolerances, in patients with incident heart failure between 2012 and 2014. ‘Month –1’ presents the average daily dose prescribed in the 30 days preceding incident heart failure. ‘Month 2’ presents the average daily dose prescribed in the second month (days 30 to 60) following incident heart failure. ‘Month 12’ presents the average daily dose prescribed in the twelfth month (days 335 to 365) following incident heart failure. ACE-I, angiotensin-converting–enzyme inhibitor; ARB, angiotensin receptor blocker.